Product Description

Renadic Powder 15s | For People with Kidney Concern

Essential Amino Acids (EAAs) as a Key Nutrient.

Product Features:

• Renadic is a protein drink which is highly recommended for individuals with protein intake limits by giving a complete nutritional support especially for stage 1 to stage 4 pre-dialysis individuals.
• Renadic provides all the 9 essential amino acids (EAAs) that is needed to rejuvenate and repair the tissues and also muscles.
• Renadic also provides probiotic strain Bifidobacterium longum of 5×109 cfu/g (5billion) for gastrointestinal health and uremic toxin removal.

What are Amino Acids?

Amino acid facts

• Amino acids are the building blocks of our body. Sufficient amino acids, especially EAAs intake can help to reduce muscle protein degradation.
• Amino acids also able to form into other complexes and substances that are required for normal function of the body.
• There are two main types of amino acids: essential amino acids (EAAs) and non-essential amino acids.
• Non-essential amino acids can be obtained from normal diets, and our body able to reuse and synthesize them.
• EAAs cannot be reused and synthesized in our body, therefore must supplied from the diets.

Consequences of EAA deficiency

• According to study, not getting enough EAAs may cause lower muscle mass in older adults.
• CKD is associated with muscular wasting and there are some concerns about potential catabolic and cachectic effects of LPD/VLPD.
• Muscle wasting is the first symptom of a deficiency of EAAs.
• Therefore, supplementation of EAAs have been shown to reduce muscle protein degradation.

Nitrogen balance and amino acid

Nitrogen accounts for 16% of protein weight. Nitrogen balance is the difference between nitrogen intake in form of dietary protein, and the amount excreted, for eg through urine, faeces, sweat and etc.

Probiotics and The Benefits

• It is becoming more widely accepted that people with CKD have altered gut flora.
• In individual with CKD, they have more pathogenic bacteria in the gut compared to ‘good bacterias’ (Stephen et al., 1998)
• The pathogenic bacteria ferment undigested excess protein in the intestine, therefore produce uremic wastes which are burden for kidneys (Ranganathan et al., 2014).
• Therefore, intake of probiotics helps to balance the intestinal flora, thus improving the digestive and immune systems.
• Balancing of the gut flora prevents overgrowth of pathogenic bacteria which produce uremic toxins (Tao et al., 2019).
• Probiotic also enhances the removal of uremic toxin wastes in the colon to reduce the kidney’s burden.
• Renadic is fortified with 5x109cfu/g (5billion) of Bifidobacterium Longum to enhance GI health, improving the immune function and aids in removal of uremic toxins.

Protein and its Concern on Kidneys

• Intake of protein produces waste in the blood.
• The metabolic products of proteins are urea, creatinine, uric acids and other nitrogenous products, and they are being excreted out, mainly through urine.
• In the setting of CKD, these compounds may accumulate and exert their uremic effects on various systems, including the immune system.

Creatinine

• It is a waste product produced by muscles from the breakdown of a compound called creatine.
• As shown above, EAAs deficiency will cause protein break down from muscle tissues to provide nutrients such as EAAs for body metabolism
• Health practitioners usually measure the level of creatinine in the blood to check kidney function and used it to access GFR readings. High levels of creatinine may indicate that the kidney is damaged and not working properly.
• However, creatinine in your blood is affected by your age, race, gender, and body size.

Urea

• Urea nitrogen is a normal waste product in the blood that comes from the breakdown of protein from the foods from body metabolism.
• It is normally removed from the blood by kidneys, but when kidney function slows down, the BUN (Blood urea nitrogen) level rises.
• High urea level in blood indicates there are high amount of uremic toxins that is not filtered due to kidney failure.

Low Protein Diets (LPD): How it works?

• LPD besides lower the production of protein wastes, it also slows down the decline of glomerular filtration rate (GFR) in CKD patients to reduce the accumulation of unexcrected waste products.
• LPD also preserves the rate of progression of advanced CKD, thus delay the need for dialysis treatments.
• For stable, non-dialysis dependent CKD individuals, a low-protein diet (LPD) is recommended with a daily intake of 0.6-0.8g/kg.
• However, despite of low protein intake, sufficient supplementation of EAAs are important to ensure normal body function and preventing of muscle loss.

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